Statins and Cardiomyocyte Metabolism, Friend or Foe?

Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, and are the cornerstone of lipid-lowering treatment.They significantly reduce cardiovascular morbidity and mortality.However, musculoskeletal symptoms are observed in 7 to 29 percent of all users.The mechanism underlying these complaints has become increasingly cl

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